USS Grayling (SSN-646), a Sturgeon-class submarine, was the fifth ship of the United States Navy to be named for the grayling, a fresh-water game fish closely related to the trout.

Grayling was deactivated on 1 March 1997, placed in commission in reserve a week later as she entered the Ship and Submarine Recycling Program, then decommissioned and stricken from the Naval Vessel Register on 18 July 1997. She was scrapped on 31 March 1998.

Her sail is now a memorial on the grounds of Portsmouth Naval Shipyard, Maine, and her anchor and chain are on display as a memorial in downtown Grayling, Michigan.